How to beat Guillotina in Mewgenics

Lose at Guillotina MeugenicsYou need to choose high-level Retired Cats for combat, equip them with poisonous and blood-flecking gear, dodge his melee attacks when attacking within range, and use grass as much as possible for lower claw slashes.

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Find every Mewgenics boss with this complete guide, where they appear by task and chapter.

This butch's old pet is a giant stray who likes to toss, breathe, and eat cats as they cross two visual stages. To succeed in his race, you need to know the right tips and best team compositions, which you will find below, so read on.

How to beat Guillotina in Mewgenics

Big cats on Mewgenics Image Credit: Edmond McMillen, Tyler Gladial

Guillotina information

Statistics

Health

400

damage

5

movement

3

Before anything else, you need to be aware of Guillotine's fighting style in order to handle it efficiently in the arena. He has two combat phases that take place in the same race. Here's a quick overview of each:

  • First step: Her health sits between 400 and 201, and she either jumps onto a tile by hurtling her way between regular walking units and critters and lands on it, picks up a nearby playable character and throws it onto a random tile, or breathes a cat and spits it out 3 to 6 tiles away.
  • Second step: When her health drops to 50% (it's 200), she transforms from a cold giant to a raging monster. She not only heals 49 hit points, bringing her health down to 249 and removing all debuffs, but her regular attacks also hit hard. She can now swallow inhaling units and swallow whole to gain 25 HP.

Tips to beat Guillotina in Mewgenics

How to beat the Guillotine in Meugnix Image via GameRant; Sources: Edmond McMillen, Tyler Gleil

  • Lock onto retired cats with levels three to six for massive one-shot damage. You can get these advanced units by taking two to three cats on an adventure and covering the journey as you upgrade your unit to the desired level, or use the Neverstone to stop stray cats from advancing, so your chosen units only level up.
  • Make sure some of your retired cats can breed extra creatures (also called familiars), as they will help you hit the guillotine during combat with your controlled turn. You can choose the necromancer class for leech spawns or have trinkets like botfly larvae or whistles for fly, flea, or maggot spawns.
  • Try to choose passive abilities and trinkets that can have poison and bleed effects on Guillotine.Because these can kill him if he has enough HP left.
  • Last but not least, Stand in tall grass for a 50% dodge chance… his arena will also have a lot of small patches, so just use water elemental effects to turn them into tall grass tiles and take advantage of dodging attacks.

If Guillotina doesn't appear, chances are you haven't completed The Boneyard map yet. A seven-day timer for his battle will appear automatically after you clear it for the first time and watch his cutscene. If you're not sure how to get to the Boneyard, you can check out our comprehensive guide that covers all the activities and areas. Meugenics For easy reference. After you watch the timer, you are pushed to participate in this battle instead of your regular adventure at the end of the game week.

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The best team compositions for Guillotina on Mewgenics

Team 1

Team 2

Necromancer


magician


religious leader


tank

hunter


religious leader


tank


Necromancer

guillotinas head mewgenics

After defeating the guillotine, You'll find a Throbbing GristleAn important item to help unlock the secret Throbbing Domain area in Act 1. She returns in her second and third form as a different house owner with different health and damage, giving two more valuable drops. The tips in this guide can help you remove all versions of him.


Mewgenics tag page cover art

systems

PC-1


issued

February 10, 2026

developer(s)

Edmond McMillen, Tyler Gleil

publisher(s)

Edmond McMillen, Tyler Gleil

Number of players

single player

Steam Deck compatibility

unknown


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